N-HYDROXY-2,2-DIMETHYLPROPANIMIDAMIDE synthesis
- Product Name:N-HYDROXY-2,2-DIMETHYLPROPANIMIDAMIDE
- CAS Number:42956-75-2
- Molecular formula:C5H12N2O
- Molecular Weight:116.16
630-18-2
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$10.00/1g
42956-75-2
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$60.00/100mg
Yield:42956-75-2 79%
Reaction Conditions:
with hydroxylamine in ethanol;water; for 1 h;Reflux;
Steps:
88.F STEP F. Intermediate 88F. Preparation of N'-hydroxypivalimidamide
To a stirred solution of pivalonitrile (20 g, 241 mmol) in ethanol (200 mL) was added 50% aqueous hydroxylamine (73.7 mL, 1203 mmol) and refluxed for 1 h. The reaction mixture was concentrated under reduced pressure and the residue was diluted with water. The mixture was stirred for 15 min and the solids were filtered off. The product was dried under high vacuum to afford (E)-N'-hydroxypivalimidamide (22 g, 189 mmol, 79% yield) as white solid. MS (ESI) 117 (M+H).
References:
WO2020/168143,2020,A1 Location in patent:Page/Page column 264; 267
630-19-3
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$13.00/1g
42956-75-2
44 suppliers
$60.00/100mg
637-91-2
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$45.00/10mg
42956-75-2
44 suppliers
$60.00/100mg