Yield:885966-33-6 75%

Reaction Conditions:

with hydroxylamine hydrochloride;sodium hydroxide in ethanol;water; for 5 h;Reflux;

Steps:

2 General procedure for synthesis of amidoximes 3p,q,s

General procedure: The solution of NaOH (2.71g, 67.93mmol) in water (20mL) was added at room temperature to the solution of polymethoxyphenylacetonitrile [40] (5.0g, 33.96mmol) and hydroxylamine hydrochloride (4.72g, 67.93mmol) in EtOH (100mL). The reaction mixture was refluxed for 5h, the solvent was evaporated in vacuo, and the residue was washed by water (3×30mL) and dried. Yield 75-80%.

References:

Tsyganov, Dmitry V.;Khrustalev, Victor N.;Konyushkin, Leonid D.;Raihstat, Mikhail M.;Firgang, Sergei I.;Semenov, Roman V.;Kiselyov, Alex S.;Semenova, Marina N.;Semenov, Victor V. [European Journal of Medicinal Chemistry,2014,vol. 73,p. 112 - 125]