N''-HYDROXYTHIOPHENE-3-CARBOXIMIDAMIDE synthesis
- Product Name:N''-HYDROXYTHIOPHENE-3-CARBOXIMIDAMIDE
- CAS Number:58905-71-8
- Molecular formula:C5H6N2OS
- Molecular Weight:142.18
1641-09-4
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$13.43/1gm:
58905-71-8
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$45.00/100mg
Yield:58905-71-8 82%
Reaction Conditions:
with hydroxylamine hydrochloride;sodium hydrogencarbonate in ethanol; for 6 h;Reflux;
Steps:
Preparation of amidoximes 1a-o
General procedure: To a stirred suspension of corresponding nitrile and hydroxylamine hydrochloride (1.5 equiv.) in EtOH (10 mL per gram of nitrile) a NaHCO3 (1.5 equiv.) was added. The reaction mixture was stirred under reflux for a 6 h. After the reaction had completed, the reaction mixture was concentrated under reduced pressure, and the residue was diluted with cold water (200 mL). The resulting precipitate was filtered off and washed with cold water (50 mL).
References:
Tarasenko, Marina;Duderin, Nikolay;Sharonova, Tatyana;Baykov, Sergey;Shetnev, Anton;Smirnov, Alexey V. [Tetrahedron Letters,2017,vol. 58,# 37,p. 3672 - 3677] Location in patent:supporting information
498-62-4
410 suppliers
$5.00/1g
58905-71-8
44 suppliers
$45.00/100mg