N-Isopropylacetamide synthesis
- Product Name:N-Isopropylacetamide
- CAS Number:1118-69-0
- Molecular formula:C5H11NO
- Molecular Weight:101.15
75-31-0
438 suppliers
$14.00/25mL
75-36-5
576 suppliers
$17.92/100G
1118-69-0
117 suppliers
$59.00/25g
Yield:1118-69-0 92%
Reaction Conditions:
with hydroxyapatite supported copper(I) oxide in acetonitrile at 50; for 0.1 h;
Steps:
General procedure for N-acetylation of amines usingHAP-Cu2O
General procedure: To a mixture of amine (1 mmol), acetyl chloride (1 mmol)in acetonitrile (5 mL) were added hydroxyapatite -Cu2O(0.1 g) under air atmosphere. The reaction mixture wasrefluxed at 50 °C for an appropriate time. The progress ofthe reaction was monitored through TLC. Upon completionof the reaction, the reaction mixture was cooled toroom temperature and filtered. The residue was washedwith water followed by EtOAc (3 × 10 mL). The productwas obtained after the removal of solvent under reducedpressure followed by crystallization from pet ether orEtOAc:pet ether or passing through column of silica andelution with EtOAc:pet ether.
References:
Gupta, Manjulla;Gupta, Monika [Journal of the Iranian Chemical Society,2016,vol. 13,# 2,p. 231 - 241]
108-24-7
0 suppliers
$14.00/250ML
75-31-0
438 suppliers
$14.00/25mL
1118-69-0
117 suppliers
$59.00/25g
563-80-4
310 suppliers
$17.00/25mL
1118-69-0
117 suppliers
$59.00/25g
201230-82-2
1 suppliers
inquiry
80-43-3
0 suppliers
$36.70/100g
75-31-0
438 suppliers
$14.00/25mL
1118-69-0
117 suppliers
$59.00/25g