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ChemicalBook CAS DataBase List N,N-Dimethylbenzamide
611-74-5

N,N-Dimethylbenzamide synthesis

10synthesis methods
-

Yield:611-74-5 75%

Reaction Conditions:

with tetrabutylammomium bromide;iodine;potassium hydroxide in water at 20; for 2.5 h;Irradiation;

Steps:

General procedure for the catalytic reactions
General procedure: A 10 mL quartz tube equipped was charged with aniline (0.70 mmol), benzoic acid (0.50 mmol), TBAB (0.5 mmol), KOH (1.0 mmol), I2 (0.10 mmol), and water (2.5 mL). The reaction mixture was stirred under irradiation of sunlight at room temperature for 2.5 h. After the reaction was completed, the organic layer was collected by ethyl acetate extraction. The solution of the crude product was concentrated in vacuo, and the residue was purified by column chromatography on a silica gel (petroleum ether/ethyl acetate=5/1) to afford the target product as a white solid.

References:

Wang, Jin;Hou, Huiqing;Hu, Yongzhi;Lin, Jin;Wu, Min;Zheng, Zhiqiang;Xu, Xiuzhi [Tetrahedron Letters,2021,vol. 65,art. no. 152801] Location in patent:supporting information

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