NIPECOTAMIDE synthesis
- Product Name:NIPECOTAMIDE
- CAS Number:4138-26-5
- Molecular formula:C6H12N2O
- Molecular Weight:128.17
98-92-0
4138-26-5
122.12 g (1.00 mol) of nicotinamide was dissolved in 500 mL of 2-propanol. To this solution was added 14.4 g of 10% palladium-carbon catalyst, followed by stirring the reaction for 4 hours at 75 °C under 0.5 MPa hydrogen pressure. Upon completion of the reaction, the palladium-carbon catalyst was removed by filtration and the filter cake was washed with 100 mL of 2-propanol. The filtrate and washings were combined and concentrated to give 126.08 g of racemic 3-piperidinecarboxamide white crystals in 98.4% yield. The structure of the product was confirmed by NMR characterization.
98-92-0
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4138-26-5
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Yield:4138-26-5 98.4%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in isopropyl alcohol at 75; under 3750.38 Torr; for 4 h;
Steps:
122.12 g (1.00 mol) of nicotinamide was dissolved in 500 mL of 2-propanol. To the resulting solution was charged 14.4 g of palladium-carbon (10%), and the solution was stirred for 4 hours at 75° C. under hydrogen pressure of 0.5 MPa. After the reaction was completed, the palladium-carbon was filtered and separated. The filtered palladium-carbon was washed with 100 mL of 2-propanol. The filtrate and the washing liquid were combined and condensed, and 126.08 g of white crystals of nipecotamide in a racemic form was obtained. The yield was 98.4%. The resultant was confirmed to be the target object by NMR.
References:
SUMITOMO CHEMICAL COMPANY, LIMITED US2012/123128, 2012, A1 Location in patent:Page/Page column 3
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