OXACYCLOTRIDECAN-2-ONE synthesis
- Product Name:OXACYCLOTRIDECAN-2-ONE
- CAS Number:947-05-7
- Molecular formula:C12H22O2
- Molecular Weight:198.3
4800-58-2
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947-05-7
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Yield:947-05-7 62%
Reaction Conditions:
with triethylamine in acetonitrile
Steps:
5 EXAMPLE 5
EXAMPLE 5 To a refluxing solution of 820 mg (2.0 mmol) of 1-ethyl-2-iodoquinolinium iodide in 50 ml of acetonitrile, there was added a solution of 108 mg (0.5 mmol) of 12-hydroxydodecanoic acid and 404 mg (4.0 mmol) of triethylamine in 40 ml of acetonitrile over a period of 8.5 hours at a continuous and uniform rate, and the reaction mixture was refluxed for an additional 30 minutes after the addition was completed. After evaporation of the solvent, the residue was separated chromatographically on a silica gel column. 1,12-dodecanolide was obtained in 62% yield.
References:
Sumitomo Chemical Company, Limited US4105673, 1978, A
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947-05-7
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20 suppliers
$48.79/1g