一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Paclitaxel
33069-62-4

Paclitaxel synthesis

7synthesis methods
The total synthesis of paclitaxel (Taxol) is described. Double Rubottom oxidation of the bis(silyl enol ether) derived from a tricarbocyclic diketone effectively installed a bridgehead olefin and C-5/C-13 hydroxy groups in a one-step operation. The novel Ag-promoted oxetane formation smoothly constructed the tetracyclic framework of paclitaxel.
Total Synthesis of Paclitaxel
The biosynthesis of paclitaxel involves the condensation of the three isoprenyl diphosphate (IPP) units with dimethylallyl diphosphate (DMAPP). Plants are unique in producing IPP and DMAPP by both the mevalonic pathway (MVA) in the cytosol or via the methylerythritol phosphate (MEP) pathway in the plastids.
Paclitaxel: biosynthesis, production and future prospects
-

Yield:33069-62-4 100%

Reaction Conditions:

with hydrogenchloride;water in ethanol at 0 - 20; for 2.41667 h;

Steps:

28

Example 28: Paclitaxel.; To a solution of 7-O-(triethylsilyl)pacl itaxel (7 mg) in ethanol (2 ml_) at 0 0C was added HCI (2 M, 2 ml_). The reaction was stirred for 2h and 25 minutes from 0 0C to room temperature. Next, EtOAc and aqueous sodium hydrogencarbonate were added at 0 0C. The mixture was extracted with dichloromethane, and the organic layer was dried over sodium sulfate. After filtration of the mixture and evaporation of the solvent, the crude product was purified by silica gel column chromatography to afford paclitaxel in quantitative yield as a white solid. 1H NMR (400 MHz, CDCI3): δ - 8.13 (d, J=8.4Hz, 2H), 7.74 (d, J=8.8Hz, 2H), 7.64-7.58 (m, 1 H), 7.53-7.46 (m, 5H), 7.44-7.34 (m, 5H), 6.98 (d, J=8.8Hz, 1 H), 6.27 (s, 1 H), 6.23 (t, J=8.8Hz, 1 H), 5.79 (dd, J=2.8Hz, J'= 6.4Hz, 1 H), 5.67 (d, J=6.8Hz, 1 H), 4.96 (d, J=8.0Hz, 1 H), 4.79 (d, J=2.4Hz, 1 H), 4.40 (dd, J=AAHz, J'=6.8Hz, 1 H), 4.30 (d, J=8.4Hz, 1 H), 4.20 (d, J=8.4Hz, 1 H), 3.80 (d, J=7.2Hz, 1 H), 3.54 (bs, 1 H), 2.59-2.50 (m, 1 H), 2.38 (s, 3H), 2.36-2.28 (m, 2H), 2.34 (s, 3H), 1.92-1.84 (m, 1 H), 1.80 (s, 3H), 1.68 (s, 3H), 1.25 (bs, 2H), 1.24 (s, 3H), 1.14 (s, 3H); 13C NMR (100 MHz, CDCI3): 203.6, 172.7, 171.3, 170.4, 167.0, 167.0, 142.0, 137.9, 133.7, 133.6, 133.2, 132.0, 130.2, 129.1 , 129.0, 129.0, 128.7, 128.7, 128.4, 127.0, 84.4, 81.2, 79.0, 76.5, 75.6, 74.9, 73.2, 72.2, 58.6, 55.0, 45.6, 43.2, 35.7, 35.6, 26.9, 22.6, 21.8, 20.8, 14.8, 9.5; HRMS (ESI): calcd for [M+Na] (C47H5I NOi4) requires m/z 876.3202, found 876.3191 : [α]D = -50.0 (c=0.1 , CHCI3); melting point: 195-197 0C.

References:

WO2010/62239,2010,A1 Location in patent:Page/Page column 21-22

Paclitaxel Related Search:

长汀县| 五台县| 柳江县| 安达市| 遂昌县| 阿坝县| 扶绥县| 巴中市| 双桥区| 莒南县| 得荣县| 武汉市| 舞阳县| 新干县| 卓资县| 增城市| 湖南省| 同德县| 田阳县| 泰和县| 苗栗县| 平果县| 高青县| 济源市| 安国市| 巫山县| 辽中县| 凤阳县| 科技| 陆川县| 达孜县| 南京市| 新竹市| 沂源县| 乳山市| 蒲城县| 怀仁县| 舞阳县| 崇阳县| 新蔡县| 日土县|