一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Paliperidone Impurity 7
1415488-05-9

Paliperidone Impurity 7 synthesis

1synthesis methods
130049-82-0 Synthesis
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

130049-82-0
322 suppliers
$55.00/1g

Paliperidone Impurity 7

1415488-05-9
26 suppliers
inquiry

-

Yield:1415488-05-9 95%

Reaction Conditions:

Stage #1: 3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one;1-hexadecylcarboxylic acidwith dmap;triethylamine in dichloromethane at 25 - 30; for 0.25 h;
Stage #2: with pivaloyl chloride in dichloromethane at 25 - 40; for 2 h;

Steps:

1

A mixture of methylene chloride, 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2- methyl-9-hydroxy-4H-pyrido[ l ,2-a] pyrimidine-4-one, palmitic acid , 4-dimethyl amino pyridine and triethylamine was stirred for 15 min at 25-30 C, pivaloyl ' chloride was added slowly to above reaction mass at 25-40 °C and the reaction was maintained for 2 hours at 30-35 °C then the reaction mass was cooled to 25 °C, charged purified water, separated the organic layer, washed the organic layer with dilute hydrochloric acid followed by water, distilled off methylene chloride completely and co distilled with acetonitrile. The resulted residue was dissolved in acetonitrile and added purified water slowly at 25-30 °C, stirred the contents for 30 minutes at the same temperature and cooled the mass to 10-15 °C stirred for 2 hours at the same temperature, filtered the isolated compound, washed the wet cake with chilled acetonitrile and dried the compound under vacuum.Yield: 95% (Theoretical).

References:

WO2012/164582,2012,A1 Location in patent:Page/Page column 10-11

Paliperidone Impurity 7 Related Search:

陇西县| 紫金县| 乌拉特前旗| 永善县| 壤塘县| 嘉义县| 徐水县| 永安市| 定州市| 库尔勒市| 邢台市| 广南县| 惠水县| 蚌埠市| 比如县| 德昌县| 鄂尔多斯市| 达日县| 常山县| 蒙阴县| 阳原县| 赣州市| 南通市| 磐安县| 德清县| 福鼎市| 涟源市| 普宁市| 安多县| 渑池县| 额济纳旗| 遵化市| 阜新市| 昭觉县| 若尔盖县| 桐柏县| 靖江市| 威远县| 鄂尔多斯市| 崇阳县| 阜城县|