Pemigatinib synthesis

6synthesis methods

Product Name:Pemigatinib
CAS Number:1513857-77-6
Molecular formula:C24H27F2N5O4
Molecular Weight:487.5

Removal of the acetaldehyde protecting group in compound 284 under acidic conditions afforded aldehyde 285. Reductive amination of aldehyde 285 with aniline 286 gave benzylamine 287. Benzylamine 287 reacted with isocyanate 288 to form the desired urea 289. In the presence of a strong base, LHMDS (lithium dimethylsilane), compound 289 underwent intramolecular cyclization to displace the adjacent chlorine atom to yield azatricyclic compound 290. Conventional hydrolysis to remove the benzenesulfonyl group completed the construction of pemitinib, affording the final product in good yield.
Pemigatinib synthesis

958230-19-8 Synthesis

4-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBALDEHYDE

958230-19-8
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$28.00/100mg

1513857-77-6
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2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)-7-(phenylsulfonyl)-

1513860-02-0
1 suppliers
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1513857-77-6
130 suppliers
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References

2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-

1513857-72-1
2 suppliers
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1513857-77-6
130 suppliers
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References

915403-16-6 Synthesis

4-(ethylamino)-1H-Pyrrolo[2,3-b]pyridine-5-carboxaldehyde

915403-16-6
23 suppliers
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1513857-77-6
130 suppliers
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References

1H-Pyrrolo[2,3-b]pyridine-5-methanamine, N-(2,6-difluoro-3,5-dimethoxyphenyl)-4-(ethylamino)-

1513859-26-1
1 suppliers
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1513857-77-6
130 suppliers
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References

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Pemigatinib synthesis