Penciclovir synthesis
- Product Name:Penciclovir
- CAS Number:39809-25-1
- Molecular formula:C10H15N5O3
- Molecular Weight:253.26
97845-60-8
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$13.00/1g
39809-25-1
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$6.00/100mg
Yield:39809-25-1 97%
Reaction Conditions:
with hydrogenchloride in water for 3 h;Reflux;Industrial scale;Time;
Steps:
1-4; 1 Example 1. Preparation of the crystal form of the present invention
Weigh compound II (978.40g, 2.75mol) and add it to 8.25L hydrochloric acid (2mol/L), and react under reflux for 3 hours. Cool to room temperature, add NaOH solution (14mol/L),Adjust the pH to 14.0. Wash with ethyl acetate,Add hydrochloric acid (6mol/L) to the water phase,Adjust the pH to neutral, and a large number of white crystals will be precipitated. After filtering, washing and drying, 675.57 g of penciclovir was obtained with a yield of 97.0percent.The chemical purity is 99.99percent.
References:
Sichuan Keruidekaihua Pharmaceutical Co., Ltd.;Li Jiang;Li Feng;Fu Lin;Zhao Youjie;Chen Gang CN111377926, 2020, A Location in patent:Paragraph 0034-0043
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172529-94-1
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39809-25-1
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97845-59-5
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39809-25-1
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7459-46-3
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39809-25-1
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6482-32-2
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39809-25-1
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