Pentafluoro-1-propanol synthesis
- Product Name:Pentafluoro-1-propanol
- CAS Number:422-05-9
- Molecular formula:C3H3F5O
- Molecular Weight:150.05
422-64-0
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422-05-9
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Yield:422-05-9 99%
Reaction Conditions:
with hydrogen;Rh/C in water at 20 - 90; under 7500.75 Torr; for 18 h;
Steps:
2.15 g of 5 wt% Rh/C catalyst was introduced together with 32.8 g of water and 39.8 g of perfluoropropionic acid at room temperature into an autoclave reactor. The reactor was then purged with helium. H2 was bubbled into the solution via a dipping tube at a flow-rate of 8 liter / h. The pressure was set to 10 bar and the reactor temperature was increased to 90°C. After 18 hours, the autoclave was cooled down to room temperature and vented. The collected liquid phase was filtered and then introduced into a decantation funnel. The lower phase containing the pentafluoropropanol was separated and distilled in the presence of anhydrous H2SO4 (30 wt%) to give pure pentafluoropropanol containing 50 ppm of water (quantitative yield measured by gas chromatography (GC)). The yield in pentafluoropropanol was 99 %.
References:
EP1820789,2007,A1 Location in patent:Page/Page column 3
1814-88-6
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422-05-9
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354-76-7
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422-05-9
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422-01-5
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422-05-9
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754-12-1
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1814-88-6
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