Phenidone synthesis
- Product Name:Phenidone
- CAS Number:92-43-3
- Molecular formula:C9H10N2O
- Molecular Weight:162.19
Yield:92-43-3 75%
Reaction Conditions:
with sodium methylate in methanol;toluene at 30;Reflux;
Steps:
Synthesis of pyrazolidin-3-ones (2a-o); general procedure
General procedure: Substituted phenyl hydrazine hydrochloride (0.02 mol) was added to a mixture of sodium methoxide (0.05 mol), anhydrous methanol (6 mL) and toluene (21 mL). Then, a solution of the α,β-unsaturated acid esters (0.06 mol) in anhydrous methanol (6 mL) was added dropwise at 30-35 °C for 0.5 h, after which the mixture was refluxed until the starting material was completely consumed as judged by TLC. After reaction completion, the mixture was evaporated under reduced pressure. Water (20 mL) was added to the residue and the pH was adjusted to 6.5. The solvent was cooled to 1 °C, allowed to standand filtered. The solid was recrystallised from ethyl acetate to give compounds 2a-o.
References:
Liu, Jingjing;Yang, Shanguang;Dong, Ruimei;Jin, Zhudan;Wang, Mingliang [Journal of Chemical Research,2018,vol. 42,# 1,p. 24 - 27]
59-88-1
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92-43-3
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3314-35-0
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92-43-3
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