PHT-MET-OH synthesis
2synthesis methods
- Product Name:PHT-MET-OH
- CAS Number:29588-91-8
- Molecular formula:C13H13NO4S
- Molecular Weight:279.31
Yield:29588-91-8 97%
Reaction Conditions:
with lemon juice at 130 - 135;
Steps:
Method B (conventional heating method)
General procedure: A mixture of the appropriate (S)-amino acid (0.10 g) and phthalic anhydride (1.3 eq) inthe presence of lemon juice (1-2 drops, 0.1 mL) was heated at 130-135 C in an oil bathfor 15-20 min, as indicated by TLC in EtOAc or EtOH. After the completion of reaction,the products were purified by crystallization as above to afford pure crystals of3a-f.
References:
Saddiqa, Aisha;Shahzadi, Iram;Usman, Muhammad;?akmak, Osman;?kten, Salih [Organic Preparations and Procedures International,2022,vol. 54,# 6,p. 583 - 593]
