PRENYL ISOBUTYRATE synthesis
- Product Name:PRENYL ISOBUTYRATE
- CAS Number:76649-23-5
- Molecular formula:C9H16O2
- Molecular Weight:156.22
Yield:-
Reaction Conditions:
with dmap;triethylamine in dichloromethane at 20; for 18 h;Inert atmosphere;
Steps:
General procedure: Prenyl methylacrylate (3-methylbut-2-enyl 2-methylprop-2-enoate; Supplementary Fig. S1b) was synthesized as follows. Methacrylic anhydride (2.0 mL, 13.42 mmol) was added dropwise to a mixture of 3- methyl-2-buten-1-ol (1.36 mL, 13.39 mmol), triethylamine (2.25 mL, 16.14 mmol), and N,N-dimethylaminopyridine (82 mg, 0.67 mmol) in dry DCM (60 mL) at room temperature under N2, and then stirred at room temperature for 18 h. The reaction mixture was directly dry-loaded onto Celite (9 g) and purified by flash chromatography on silica gel eluting with DCM/hexanes to give the target compound as a colorless oil (1.268 g, 8.22 mmol).
References:
Terry, L. Irene;Moore, Chris J.;Roemer, Robert B.;Brookes, Dean R.;Walter, Gimme H. [Phytochemistry,2021,vol. 186,art. no. 112715]
