Quinoline, 7-fluoro-4-methyl- (9CI) synthesis
1synthesis methods
- Product Name:Quinoline, 7-fluoro-4-methyl- (9CI)
- CAS Number:144147-01-3
- Molecular formula:C10H8FN
- Molecular Weight:161.18
Yield:144147-01-3 21%
Reaction Conditions:
Stage #1: meta-fluoroaniline;methyl vinyl ketone in ethanol at 0 - 20; for 19 h;Condensation;
Stage #2: with iron(III) chloride;zinc(II) chloride at 70; for 13 h;Cyclization;
References:
Kato, Taka-Aki;Hakura, Atsushi;Mizutani, Takaharu;Saeki, Ken-Ichi [Mutation Research - Genetic Toxicology and Environmental Mutagenesis,2000,vol. 465,# 1-2,p. 173 - 182]