(R)-(-)-3-Chloro-1,2-propanediol synthesis
- Product Name:(R)-(-)-3-Chloro-1,2-propanediol
- CAS Number:57090-45-6
- Molecular formula:C3H7ClO2
- Molecular Weight:110.54
Method 1 (CN202111237118.2):
After mixing and reacting (R)epichlorohydrin, (RR)Salen cobalt(III) catalyst completely, diluting with water, filtering, separating out the precipitate of (RR)Salen cobalt(III) catalyst, and then distilling the water
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57090-45-6
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Yield:57090-45-6 95.57%
Reaction Conditions:
with (R)-2-chloropropionic acid in water at 80 - 90; for 15 h;Reagent/catalyst;Temperature;
Steps:
1
92.5 g (1 mol) of (R) -epichlorohydrin (chemical purity: 99.6%, chiral purity: 99.5% e.e)36 g (1.5 mol) of distilled water and 1 g of L-2-chloropropionic acid were put into a 500-ml reaction flask and heated to 80-90 ° C with stirring,The reaction was carried out for 15 hours, Gas chromatography detection of raw materials (R) - epichlorohydrin reaction complete.Cooled to room temperature, 0.1N sodium hydroxide solution to adjust PH value to 6 ~ 7.15-20 Hgmm vacuum distillation excess water,Then, 105.6 g of (R) -3-chloro-1,2-propanediol was distilled at a high vacuum of 5-10 Hgmm and the yield was 95.57%.Analysis by gas chromatography Chemical purity:99.2%, chiral purity: 99.3% e.e.
References:
Biological Pharmaceutical Co., Ltd.;Li, Hailin;Wang, Shiyun;Zhang, Jianxian;Chen, Lin;Zhang, Aiqiang;Zhang, Zhixin CN106187678, 2016, A Location in patent:Paragraph 0027; 0028
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