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ChemicalBook CAS DataBase List rac 2-Hydroxy Ibuprofen
51146-55-5

rac 2-Hydroxy Ibuprofen synthesis

7synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: m-chloroperbenzoic acid / CH2Cl2 / 2 h / 35 °C
2: 1.) potassium tert-butoxide, 2.) HCl / 1.) THF, 15 deg C, 2 h; 2.) THF, 15 deg C, 20 min
3: 100 percent / H2 / Pd/C / tetrahydrofuran / 1.5 h / 2585.7 Torr / Ambient temperature

References:

Kurtz, Richard R.;Houser, David J. [Journal of Organic Chemistry,1981,vol. 46,# 1,p. 202 - 203]

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