Sodium D-pantothenate synthesis
- Product Name:Sodium D-pantothenate
- CAS Number:867-81-2
- Molecular formula:C9H16NNaO5
- Molecular Weight:242.23
16690-93-0
599-04-2
867-81-2
The general procedure for the synthesis of sodium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propionate from sodium 3-aminopropionate and dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone was as follows: 55.5 g of sodium 3-aminopropionate and 65 g of dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone were dissolved in 350 ml of anhydrous ethanol and heated to reflux for 3 hours. After completion of the reaction, the reaction mixture was filtered while hot and the reaction vessel was washed with 50 ml of ethanol. The washed solution was combined with the filtrate and the combined filtrate was allowed to stand at 0 °C for 5 days. Subsequently, it was filtered and the resulting solid was washed with a small amount of ethanol. Finally, the solid was dried to constant weight under reduced pressure at room temperature to obtain 76.3 g of white crystalline powder, namely sodium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propionate (sodium D-pantothenate), whose crystal structure is as described in GB565976.
Yield:867-81-2 76.3 g
Reaction Conditions:
in ethanol for 3 h;Reflux;
Steps:
1 Comparative Example 1 Preparation of sodium D-pantothenate crystals described in GB565976
55.5 g of sodium β-alaninate,Pantolactone 65 grams,Dissolved in 350 ml of absolute ethanol,Heated to reflux for 3 hours,Filtered while still hotThe reaction vessel was washed with 50 ml of ethanol,After the washing solution was filtered and the reaction mixture was combined,The filtrate was placed at 0 for 5 days,Filter, wash the solid with a little ethanol,Drying to constant weight at room temperature under reduced pressure,Got 76.3 grams of white crystalline powder,Which is the sodium D-pantothenate crystal described in GB565976.
References:
Chengdu Qiaofeng Science And Technology Co., Ltd.;Li Peng CN104761463, 2017, B Location in patent:Paragraph 0032; 0033