ChemicalBook CAS DataBase List Sodium propionate

Sodium propionate synthesis

12synthesis methods

Product Name:Sodium propionate
CAS Number:137-40-6
Molecular formula:C3H6O2.Na
Molecular Weight:96.06

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Yield:-

Reaction Conditions:

with water;sodium hydroxide in methanol at 173 - 175; under 7500.75 - 11251.1 Torr; for 9.5 h;Inert atmosphere;Temperature;Pressure;Reagent/catalyst;

Steps:

D-3 Example D-3: Hydrolysis of N-tertiary butyl propanamide to tertiary butylamine and sodium propionate salt.

The solution of N-tertiary butyl propanamide in methanol as stated under Examples B-l to B-5 was transferred to 5-L capacity high pressure stirred reactor. Then 350 gm of 48% Caustic lye in 1250 gm of water was charged to the reactor equipped with heating jacket, internal cooling coil, pressure gauge, vent valve and pressure regulator, vent condenser and product receiver. After initial flushing with nitrogen, the reaction mass was heated till 173°C to 175°C under autogenous pressure of 10 to 15 kg-g/cm , any excess pressure above this pressure was slowly released through vent condenser and the product tert-butylamine with methanol along with small amount of water was allowed to condense and was collected continuously in the receiver. The reaction was continued for nine and half hour. Once the excess pressure generation was complete and desired quantity of product was collected, the reaction mixture containing mainly solution of sodium propionate in water was cooled. Which was treated to isolate pure sodium propionate in crystalline form as explained under Example F-2. The distillate which contains tert-butylamine in methanol and water was further processed to isolate pure tert-butylamine as explained under Example F- (0085) 1.

References:

WO2021/224934,2021,A1 Location in patent:Page/Page column 16-17

920-38-7 Synthesis