Solifenacin Impurity 2 synthesis
- Product Name:Solifenacin Impurity 2
- CAS Number:1229227-22-8
- Molecular formula:C22H18N2O4
- Molecular Weight:374.39
17507-05-0
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Yield:-
Steps:
Multi-step reaction with 3 steps
1: sodium tetrahydroborate; iodine / tetrahydrofuran / 16 h / Inert atmosphere; Reflux
2: hydrogenchloride; borane-ammonia complex / aq. phosphate buffer / 37 °C / pH 7.8
3: triethylamine / tetrahydrofuran / 2 h / 0 - 25 °C / Inert atmosphere
References:
Ghislieri, Diego;Green, Anthony P.;Pontini, Marta;Willies, Simon C.;Rowles, Ian;Frank, Annika;Grogan, Gideon;Turner, Nicholas J. [Journal of the American Chemical Society,2013,vol. 135,# 29,p. 10863 - 10869]