Sulfapyridine synthesis
- Product Name:Sulfapyridine
- CAS Number:144-83-2
- Molecular formula:C11H11N3O2S
- Molecular Weight:249.29
1028-11-1
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144-83-2
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Yield:144-83-2 81%
Reaction Conditions:
with iron;ammonium chloride in methanol at 80; for 3 h;Temperature;Solvent;
Steps:
1.2 p-nitrobenzenesulfonamide pyridine is reduced to p-aminobenzenesulfonamide pyridine:
A solution of p-nitrobenzenesulfonamide pyridine (1 mmol) in nano Fe powder (3 mmol), NH4Cl (5 mmol) and methanol solvent,The reaction was stirred at 80 ° C for 3 hours.After the reaction was cooled, the mixture was diluted with AcOEt, filtered, and the filtrate was steamed to precipitate the product.Add water in the precipitate, add sodium bicarbonate to maintain the aqueous solution was alkaline, and then cooled in an ice bath to precipitate a white solid,Filtration and drying gave p-aminobenzenesulfonamide pyridine in 81% yield.
References:
South China Agricultural University;Tang, Riyuan;Xu, Li;Zhang, Junrong;Liao, Yanyan CN106316938, 2017, A Location in patent:Paragraph 0038; 0039; 0040; 0041; 0042
19077-98-6
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144-83-2
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504-29-0
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144-83-2
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121-60-8
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144-83-2
360 suppliers
$5.00/1g