Temozolomide synthesis
- Product Name:Temozolomide
- CAS Number:85622-93-1
- Molecular formula:C6H6N6O2
- Molecular Weight:194.15
114601-31-9
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85622-93-1
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$5.00/50mg
Yield:85622-93-1 98.6%
Reaction Conditions:
with hydrogenchloride;lithium hydroxide monohydrate;glacial acetic acid at 20;
Steps:
17-21 Example 17
At room temperature, compound I-3 (0.88g, 5.0mmol) was dissolved in a mixed solution of glacial acetic acid (11ml) and concentrated hydrochloric acid (22ml), and the reaction was carried out at room temperature. After the reaction was detected, the reaction solution was cooled to -5°C and stirred The solid was precipitated, filtered, and the filter cake was added to DMSO (5ml) for slurrying, filtered, and the filter cake was washed with ethanol (5ml×2) The obtained filter cake is a white light powder solid and is temozolomide, Yield 98.6%, purity 99.89%.
References:
CN114591247,2022,A Location in patent:Paragraph 0110-0120
188612-53-5
66 suppliers
inquiry
85622-93-1
539 suppliers
$5.00/50mg
188612-53-5
66 suppliers
inquiry
85622-93-1
539 suppliers
$5.00/50mg
![1,5-dihydro-4H-imidazo[4,5-d]-1,2,3-triazin-4-one](/CAS/GIF/4656-86-4.gif)
4656-86-4
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$149.00/y0000734