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ChemicalBook CAS DataBase List Trifluoperazine
117-89-5

Trifluoperazine synthesis

1synthesis methods
Trifluoperazine, 2-trifluoromethyl-10-[3-(4-methyl-1-piperazinyl) propyl]- phenothazine (6.1.5), is synthesized in the manner described above of alkylation using 2- trifluoromethylphenothazin-4-methyl-1-piperazinylpropylchloride [11,17–20].
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: NaH / dimethylformamide / 2 h / 80 °C
1.2: NaI / acetone / 48 h / Heating
2.1: K3PO4 / dimethylformamide / 2 h / 80 °C

References:

Madrid, Peter B.;Polgar, Willma E.;Toll, Lawrence;Tanga, Mary J. [Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,# 11,p. 3014 - 3017]

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