Val-cit-PAB-OH synthesis
- Product Name:Val-cit-PAB-OH
- CAS Number:159857-79-1
- Molecular formula:C18H29N5O4
- Molecular Weight:379.45
159858-22-7
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159857-79-1
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$32.00/5mg
Yield:159857-79-1 100%
Reaction Conditions:
with diethylamine in N,N-dimethyl-formamide for 24 h;
Steps:
5 Synthesis of (S)-2-((S)-2-amino-3-methylbutanamido)-N-(4-(hydroxymethyl)phenyl)- 5-ureidopentanamide 6:
Compound 5 (4.0 g, 6.65 mmol) was dissolved in DMF (80 mL) and diethyl amine (14 mL) was added. The reaction mixture was stirred for 24 hours. [0560] The reaction mixture was evaporated to dryness to give a residue. The residue was titurated with dichloromethane to give a light brown solid in 2.5 g for a quantitative yield. The compound was used in the next step without further purification.
References:
IL-2RX, INC.;SOARES, Luis R.B.;HURT, Clarence Ray WO2020/14541, 2020, A2 Location in patent:Paragraph 0546; 0551; 0559-0560
870487-04-0
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86060-87-9
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159857-79-1
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$32.00/5mg
870487-09-5
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159857-79-1
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![L-Ornithinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-](/CAS/20200515/GIF/159858-07-8.gif)
159858-07-8
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159857-79-1
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68858-20-8
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159857-79-1
229 suppliers
$32.00/5mg