ChemicalBook CAS DataBase List Velpatasvir-A12

Velpatasvir-A12 synthesis

11synthesis methods

Product Name:Velpatasvir-A12
CAS Number:1377604-63-1
Molecular formula:C49H56N8O8
Molecular Weight:885.02

1378391-43-5
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1377604-63-1
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Yield:-

Steps:

Multi-step reaction with 3 steps
1: ammonium acetate / toluene; 2-methoxy-ethanol / 4.5 h / 110 °C
2: hydrogenchloride / dichloromethane; 1,4-dioxane / 0.5 h / 20 °C
3: N-ethyl-N,N-diisopropylamine; 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate / N,N-dimethyl-formamide / 0.33 h / 20 °C

References:

WO2013/75029,2013,A1

(2S,4S)-1-tert-butyl 2-(2-oxo-2-(8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]
chromen-3-yl)ethyl) 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate

1378391-39-9
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1377604-63-1
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References

1378391-42-4
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1377604-63-1
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References

1378391-44-6
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1377604-63-1
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References

487048-28-2 Synthesis

N-BOC-CIS-4-CYANO-L-PROLINE METHYL ESTER

487048-28-2
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1377604-63-1
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References

Velpatasvir-A12 Related Search:

(R)-2-(methoxycarbonylamino)-2-phenylacetic acid Velpatasvir Velpatasvir intermediate N-BOC-CIS-4-CYANO-L-PROLINE METHYL ESTER ABT-199 Methyl 2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazin-1-yl]benzoate 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid

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Velpatasvir-A12 synthesis

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