一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List VILAZODONE
163521-12-8

VILAZODONE synthesis

3synthesis methods
143612-79-7 Synthesis
3-(4-Chlorbutyl)-1H-indol-5-carbonitril

143612-79-7
334 suppliers
$23.00/1g

VILAZODONE

163521-12-8
253 suppliers
inquiry

-

Yield:163521-12-8 95.7%

Reaction Conditions:

Stage #1:3-(4-chlorobutyl)-5-cyanoindole with sodium iodide in N,N-dimethyl-formamide at 25 - 30; for 0.25 h;
Stage #2:5-(1-piperazinyl)benzofuran-2-carboxamide with tetrabutylammomium bromide;sodium hydrogencarbonate in N,N-dimethyl-formamide at 110 - 115; for 1.25 h;Reagent/catalyst;Temperature;Time;Solvent;

Steps:

11.11e Preparation of Form I of vilazodone free base
To a solution of 3-(4-chlorobutyl)-1 H-indole-5-carbonitrile (2.5 g) in DMF (10 mL), sodium iodide (0.8 g) was added and the reaction mass was stirred at about 25-30 °C for 15 minutes. Sodium bicarbonate (3.61 g), 5-(piperazin-1 -yl)benzofuran-2- carboxamide (3 g) and tetrabutylammonium bromide (0.51 g) was added to the reaction mass and heated to 110-115 °C for 1 hour and 15 minutes. The reaction mass was then allowed to cool to 60 °C and water (37.5 mL) was added to the reaction mass slowly. The resulting precipitate was stirred for 60 minutes at about 30 °C. The precipitate was filtered, washed with water (10 mL) and dried for 5-6 hours at 60 °C under vacuum to afford the desired compound.Yield: 4.5 g (95.7 %). Purity (by HPLC): 97.39 %

References:

DR.REDDYS LABORATORIES LIMITED;IQBAL, Javed;ORUGANTI, Srinivas;RAPOLU, Rajesh Kumar;PEDDY, Vishweshwar;BOGE, Rajesham;PATHIVADA, Deepika;VELAGA, Dharma Jagannadha Rao;YARRAGUNTLA, Sesha Reddy;BADDAM, Sudhakar Reddy;NAREDLA, Anitha;DONIPARTHI, Kiran Kumar;NADGOUD, Ramesh Kumar;PAGADALA, Narasimha Rao;UNNIARAN, Syam Kumar;RAMAKRISHNAN, Srividya WO2013/168126, 2013, A1 Location in patent:Page/Page column 75-78

FullText

1422956-25-9 Synthesis
5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxylic acid ethyl ester hydrochlorid

1422956-25-9
4 suppliers
inquiry

VILAZODONE

163521-12-8
253 suppliers
inquiry

VILAZODONE Related Search:

湘潭县| 宜丰县| 青铜峡市| 泰安市| 收藏| 壤塘县| 尚志市| 福鼎市| 固镇县| 抚远县| 大化| 台南市| 韩城市| 天等县| 潢川县| 阳信县| 金门县| 皮山县| 醴陵市| 朝阳区| 田阳县| 双鸭山市| 松桃| 登封市| 洛南县| 舒城县| 临夏县| 四子王旗| 安顺市| 岢岚县| 驻马店市| 景宁| 成安县| 永安市| 固始县| 嘉黎县| 天津市| 柳林县| 盐山县| 定兴县| 城市|