Z-DL-ASPARAGINE synthesis
- Product Name:Z-DL-ASPARAGINE
- CAS Number:29880-22-6
- Molecular formula:C12H14N2O5
- Molecular Weight:266.25
3130-87-8
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$7.00/10g
501-53-1
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$10.00/1g
29880-22-6
106 suppliers
$8.00/1g
Yield: 90.3%
Reaction Conditions:
with sodium carbonate in acetone; pH=8 - 9 at 0 - 20;Large scale;
Steps:
1.1; 2.1; 3.1
In the first step, 100G asparagine is suspended in a mixture of 1000G water and 300G acetone, and stirred.Adjust the pH between 8-9 with a 20% sodium carbonate solution and cool to 0 °C.Slowly add benzyl chloroformate 150G, keep the temperature below 3 °C, add 1~2 hours,The temperature was then raised to between 18 and 20 ° C and the reaction was carried out for 10 hours.TLC detection, the reaction of the starting material was completed, and acidified to pH=1 with 4 equivalents of hydrochloric acid to precipitate a solid.The intermediate N-benzyloxycarbonyl asparagine was obtained by filtration and dried to give a solid 182 g (yield: 90.3%).
References:
Jier Biochemical (Shanghai) Co., Ltd.;Shanghai Jier Polypeptide Co., Ltd.;Xu Hongyan;Li Zhongcai CN109535035, 2019, A Location in patent:Paragraph 0012; 0014; 0016
3130-87-8
241 suppliers
$7.00/10g
29880-22-6
106 suppliers
$8.00/1g