Z-LEU-SER-OME synthesis
- Product Name:Z-LEU-SER-OME
- CAS Number:40290-56-0
- Molecular formula:C18H26N2O6
- Molecular Weight:366.41
2018-66-8
351 suppliers
$8.00/5g
2788-84-3
30 suppliers
$367.00/0.25G
40290-56-0
16 suppliers
$28.60/50mg
Yield:40290-56-0 78%
Reaction Conditions:
with benzotriazol-1-ol;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;N-ethyl-N,N-diisopropylamine in dichloromethane;water at 20; for 18 h;
Steps:
General Procedure: Peptide coupling reaction
General procedure: To a stirred solution of the N-protected amino acid derivative (1.0 eq) in dry CH2Cl2 (50-75 mM)was added EDC (1.3 eq), HOBt·H2O (1.5 eq) and DIPEA (3.0 eq). The solution was stirred at rtovernight, diluted with CH2Cl2 and the organic layer washed twice with 1M HCl(aq), saturatedaqueous NaHCO3(aq) and brine. The organic layer was dried over MgSO4(s) and the solventremoved in vacuo. See individual experiments for details.
References:
Pehere, Ashok D.;Nguyen, Steven;Garlick, Sarah K.;Wilson, Danny W.;Hudson, Irene;Sykes, Matthew J.;Morton, James D.;Abell, Andrew D. [Bioorganic and Medicinal Chemistry,2019,vol. 27,# 2,p. 436 - 441] Location in patent:supporting information
2018-66-8
351 suppliers
$8.00/5g
5680-80-8
465 suppliers
$10.00/5g
40290-56-0
16 suppliers
$28.60/50mg
2018-66-8
351 suppliers
$8.00/5g
40290-56-0
16 suppliers
$28.60/50mg
3397-35-1
107 suppliers
$9.00/1G
2788-84-3
30 suppliers
$367.00/0.25G
40290-56-0
16 suppliers
$28.60/50mg