Z-MEILE-OH synthesis
- Product Name:Z-MEILE-OH
- CAS Number:4125-97-7
- Molecular formula:C14H21NO2
- Molecular Weight:235.32
50-00-0
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1859-49-0
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4125-97-7
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$22.00/250mg
Yield:4125-97-7 88.3%
Reaction Conditions:
with formic acid in water at 90; for 2 h;
Steps:
6 N-Benzyl-N-methyl-L-isoleucine (Bn-MeIle-OH)
To 110.7 g of above described N-benzyl-isoleucine (0.50 mol) were added 69.0 g formic acid (1.50 mol) and 49.4 g formaldehyde 36.5% in water (0.60 mol) and the clear, colorless reaction mixture was heated under stirring to ~90° C. for 2 h. The reaction mixture was concentrated by rotary evaporation (60° C./25 mbar) and the residue was triturated under stirring (15 min) with 250 ml acetone. After evaporation of the solvent, triturating was repeated twice using a total of 500 ml acetone. Evaporation of the solvent (50° C./10 mbar) gave 129.9 g white, crystalline residue which was stirred with 200 ml acetone for 1 h at RT and 3 h at -20° C. The crystal suspension was filtered, washed with cold acetone and dried (16 h/50° C./10 mbar) affording 103.9 g (88.3%) product as a white, crystalline powder.
References:
US2005/272665,2005,A1 Location in patent:Page/Page column 11
73-32-5
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4125-97-7
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$22.00/250mg
100-52-7
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4125-97-7
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$22.00/250mg
658691-27-1
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4125-97-7
59 suppliers
$22.00/250mg
1859-49-0
72 suppliers
$23.30/1G
4125-97-7
59 suppliers
$22.00/250mg