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Technical Data Sheet AZD 3759
Compound Information
Product Name:
AZD 3759
CAS No.:
1626387-80-1
Molecular Formula:
C22H23ClFN5O3
Molecular Weight:
459.9
Storage:
Powder -20°C 3 years; 4°C 2 years
In solvent -80°C 6 months; -20°C 1 month
In solvent -80°C 6 months; -20°C 1 month
Revision Date:
2026-04-15
Analytical Information
| Tests | Specifications |
|---|---|
| Description | AZD3759 (Zorifertinib) is a potent, oral active, CNS-penetrant EGFR inhibitor with IC50 of 0.3 nM, 0.2 nM, and 0.2 nM for EGFR (WT), EGFR (L858R), and EGFR (exon 19Del), respectively. |
| Form | solid |
| Color | White to off-white |
| Solubility | ≥23 mg/mL in DMSO; insoluble in H2O; ≥8.32 mg/mL in EtOH with ultrasonic |
| Purity | >99.0% |
| NMR | Pass test |
Disclaimer: This information relates only to the specific material designated and may not be valid for such material used in combination with anyother materials or in any other process. Such information is to be the best of the company's knowledge and believed accurate and reliable as of thedate indicated. However, no representation, warranty or guarantee of any kind, express or implied, is made as to its accuracy, reliability orcompleteness and we assume no responsibility for any loss, damage or expense, direct or consequential, arising out of use. It is the user'sresponsibility to satisfy himself as to the suitableness & completeness of such information for his own particular use.
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