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Technical Data Sheet Upadacitinib
Compound Information
Product Name:
Upadacitinib
CAS No.:
1310726-60-3
Molecular Formula:
C17H19F3N6O
Molecular Weight:
380.37
Storage:
Store at -20°C
Revision Date:
2026-04-27
Analytical Information
| Tests | Specifications |
|---|---|
| Description | Upadacitinib (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cy |
| IUPAC Name | (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide |
| Form | A crystalline solid |
| Color | White to off-white |
| Solubility | DMSO:42.67(Max Conc. mg/mL);112.17(Max Conc. mM) DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.31(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);78.87(Max Conc. mM) Ethanol:76.0(Max Conc. mg/mL);199.8(Max Conc. mM) |
| HPLC | Shows 99.7% purity |
| 1H NMR | Pass test |
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