| Identification | Back Directory | [Name]
OXCARBAZEPINE-D4 | [CAS]
1134188-71-8 | [Synonyms]
TRILEPTAL-D4
OXCARBAZEPINE-D4
10,11-DIHYDRO-10-OXO-5H-DIBENZ[B,F]AZEPINE-5-CARBOXAMIDE-D4
1,2,3,4-tetradeuterio-5-oxo-6H-benzo[b][1]benzazepine-11-carboxamide | [Molecular Formula]
C15H8D4N2O2 | [MDL Number]
MFCD07369623 | [MOL File]
1134188-71-8.mol | [Molecular Weight]
256.29 |
| Chemical Properties | Back Directory | [Boiling point ]
457.236±55.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.329±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble | [form ]
A solid | [pka]
13.733±0.20(predicted) |
| Hazard Information | Back Directory | [Description]
Oxcarbazepine-d4 is intended for use as an internal standard for the quantification of oxcarbazepine by GC- or LC-MS. Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine . It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 μM. Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50s = 10-20 mg/kg), as well as seizures induced by pentylenetetrazole (PTZ; ) or picrotoxin in rodents (ED50s = 23-30 and 150-250 mg/kg, respectively). Formulations containing oxcarbazepine have been used in the treatment of epileptic seizures. | [Uses]
Oxcarbazepine-d4-1 is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Ashley M Thomas, et al. Old Friends With New Faces: Are Sodium Channel Blockers the Future of Adjunct Pain Medication ManagementJ Pain. 2018 Jan;19(1):1-9. DOI:10.1016/j.jpain.2017.08.001
[3] Ching-Yi Lee,et al. The effects of antiepileptic drugs on the growth of glioblastoma cell lines. J Neurooncol. 2016 May;127(3):445-53. DOI:10.1007/s11060-016-2056-6
[4] M Schmutz, et al. Oxcarbazepine: preclinical anticonvulsant profile and putative mechanisms of action. Epilepsia. 1994;35 Suppl 5:S47-50. DOI:10.1111/j.1528-1157.1994.tb05967.x |
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