1134188-71-8
中文名稱
奧卡西平-D4
英文名稱
OXCARBAZEPINE-D4
CAS
1134188-71-8
分子式
C15H8D4N2O2
分子量
256.29
MOL 文件
1134188-71-8.mol
更新日期
2025/09/04 19:54:01
1134188-71-8 結構式
基本信息
中文別名
奧卡西平-D4 英文別名
TRILEPTAL-D4OXCARBAZEPINE-D4
10,11-DIHYDRO-10-OXO-5H-DIBENZ[B,F]AZEPINE-5-CARBOXAMIDE-D4
1,2,3,4-tetradeuterio-5-oxo-6H-benzo[b][1]benzazepine-11-carboxamide
應用領域
用途一
Oxcarbazepine-d4 is intended for use as an internal standard for the quantification of oxcarbazepine by GC- or LC-MS. Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine . It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 μM. Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50s = 10-20 mg/kg), as well as seizures induced by pentylenetetrazole (PTZ; ) or picrotoxin in rodents (ED50s = 23-30 and 150-250 mg/kg, respectively). Formulations containing oxcarbazepine have been used in the treatment of epileptic seizures.常見問題列表
概述
奧卡西平-D4 是 Oxcarbazepine 氘代物。Oxcarbazepine 是一種鈉通道 (sodium channel) 阻滯劑。Oxcarbazepine 有效抑制膠質(zhì)母細胞瘤細胞生長并誘導膠質(zhì)母細胞瘤細胞凋亡 (apoptosis) 或 G2/M 停滯。具有抗癌和抗驚厥作用。