| Identification | Back Directory | [Name]
AMNA | [CAS]
1175954-87-6 | [Synonyms]
AMNA
ARACHIDONOYL M-NITROANILINE
Arachidonoyl m-Nitroaniline Exclusive
N-(3-NITROPHENYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE
(5Z,8Z,11Z,14Z)-N-(3-nitrophenyl)icosa-5,8,11,14-tetraenamide | [Molecular Formula]
C26H36N2O3 | [MDL Number]
MFCD08062240 | [MOL File]
1175954-87-6.mol | [Molecular Weight]
424.58 |
| Chemical Properties | Back Directory | [Boiling point ]
591.7±50.0 °C(Predicted) | [density ]
1.045±0.06 g/cm3(Predicted) | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (1:4): 1 mg/ml; Ethanol: 50 mg/ml | [pka]
14.03±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
Arachidonoyl m-Nitroaniline (AmNA) is one of several nitroaniline fatty acid amides which can be used to measure fatty acid amide hydrolase (FAAH) activity.1 FAAH is a relatively unselective enzyme in that it accepts a variety of amide head groups other than the ethanolamine of its nominal endogenous substrate anandamide (arachidonyl ethanolamide; AEA). It also will hydrolyze fatty acid amides with fewer carbons and fewer double bonds than arachidonate (see also Decanoyl m-Nitroaniline; ). Exposure of AmNA to FAAH activity results in the release of the yellow colorimetric dye m-nitroaniline (ε = 13,500 at 410 nm). This offers the potential for fast and convenient measurements of FAAH activity using a 96 well plate spectrophotometer. | [Uses]
Arachidonoyl m-Nitroaniline (AmNA) is one of several nitroaniline fatty acid amides which can be used to measure fatty acid amide hydrolase (FAAH) activity. Arachidonoyl m-Nitroaniline is a FAAH substrate[1][2]. | [References]
1. Patricelli, M.P., and Cravatt, B.F. Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase Biochemistry 40(20),6107-6115(2001). |
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