| Identification | Back Directory | [Name]
PCUHBNWYHLQSBO-HQRMLTQVSA-N | [CAS]
120205-58-5 | [Synonyms]
PCUHBNWYHLQSBO-HQRMLTQVSA-N
Monomethyl auristatin E intermediate-9
(3R,4S,5S)-tert-butyl 4-(((benzyloxy)carbonyl)(methyl)amino)-3-methoxy-5-methylheptanoate | [Molecular Formula]
C22H35NO5 | [MOL File]
120205-58-5.mol | [Molecular Weight]
393.517 |
| Hazard Information | Back Directory | [Uses]
Monomethyl auristatin E intermediate-9 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1]. | [References]
[1] Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87. DOI:10.1158/0008-5472.CAN-14-1931 |
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