| Identification | Back Directory | [Name]
(3R,4S,5S)-tert-butyl 4-(benzyl(methyl)amino)-3-methoxy-5-methylheptanoate | [CAS]
870640-64-5 | [Synonyms]
(3R,4S,5S)-tert-butyl 4-(benzyl(methyl)amino)-3-methoxy-5-methylheptanoate
tert-butyl (3R,4S,5S)-4-(benzyl(methyl)amino)-3-methoxy-5-methylheptanoate
Heptanoic acid, 3-methoxy-5-methyl-4-[methyl(phenylmethyl)amino]-, 1,1-dimethylethyl ester, (3R,4S,5S)- | [Molecular Formula]
C21H35NO3 | [MDL Number]
MFCD28385890 | [MOL File]
870640-64-5.mol | [Molecular Weight]
349.51 |
| Hazard Information | Back Directory | [Uses]
Monomethyl auristatin E intermediate-13 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1]. | [References]
[1] Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87. DOI:10.1158/0008-5472.CAN-14-1931 |
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