| Identification | Back Directory | [Name]
D-erythro-sphinganine-d7 | [CAS]
1246304-35-7 | [Synonyms]
sphinganine-d7
Sphinganine-d7 (d18:0)
D-erythro-sphinganine-d7
D-ERYTHRO-SPHINGANINE-D7;SPHINGANINE-D7 | [Molecular Formula]
C18H39NO2 | [MDL Number]
MFCD22416901 | [MOL File]
1246304-35-7.mol | [Molecular Weight]
301.52 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMF: 10 mg/mL; DMSO: 2 mg/mL; Ethanol: miscible | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Sphinganine-d7 (d18:0) is intended for use as an internal standard for the quantification of sphinganine (d18:0) by GC- or LC-MS. Sphinganine (d18:0) is a precursor to ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate .1 Sphinganine (d18:0) levels increase significantly in response to certain mycotoxins, including fumonisins, as well as in some cancers.2,3,4
| [Uses]
D-Erythro-dihydrosphingosine-d7 is the deuterium labeled D-Erythro-dihydrosphingosine. D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity. | [References]
1. Smith, E.R., and Merrill, A.H., Jr. Differential roles of de novo sphingolipid biosynthesis and turnover in the “Burst” of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivatives, that occurs upon changing the medium of cells in culture J. Biol. Chem. 270(32),18749-18758(1995).
2. Pruett, S.T., Bushnev, A., Hagedorn, K., et al. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols J. Lipid Res. 49(8),1621-1639(2008).
3. Shephard, G.S., van der Westhuizen, L., and Sewram, V. Biomarkers of exposure to fumonisin mycotoxins: A review Food Addit. Contam. 24(10),1196-1201(2007).
4. Yin, J., Miyazaki, K., Shaner, R.L., et al. Altered sphingolipid metabolism induced by tumor hypoxia - new vistas in glycolipid tumor markers FEBS Lett. 584(9),1872-1878(2010). |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|