| Identification | Back Directory | [Name]
Bis-PEG10-acid | [CAS]
1268488-70-5 | [Synonyms]
1268488-70-5 Bis-PEG9-COOH HOOC-PEG8-COOH Bis-PEG10-acid Bis-PEG25-acid COOH-PEG8-COOH HOOCCH2CH2O-PEG8-CH2CH2COOH HOOCCH2CH2-PEG24-CH2CH2COOH Bis-PEGn-CH2CH2COOH (n=9,25) α,ω-dipropionic acid octaethylene glycol 4,7,10,13,16,19,22,25,28-Nonaoxahentriacontanedioic acid | [Molecular Formula]
C22H42O13 | [MDL Number]
MFCD28334514 | [MOL File]
1268488-70-5.mol | [Molecular Weight]
514.56 |
| Chemical Properties | Back Directory | [Boiling point ]
630.0±55.0 °C(Predicted) | [density ]
1.174±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [form ]
Solid | [pka]
3.97±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Bis-PEG9-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
Bis-??PEG9-??acid is used in the preparation of plasma-stable dimeric inhibitors of PSD-95-NMDA receptor interaction. | [Biological Activity]
Bis-PEG10-acid is a PROTAC linker belonging to the PEG class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). | [target]
| PEGs | Cleavable | table>[IC 50]
PEGs; Cleavable Linker |
|
|
|
Tags:1268488-70-5
Related Product Information
|
|
1246189-43-4
31127-85-2
439114-13-3
19364-66-0
119189-70-7
2055023-26-0
96517-92-9
51178-68-8
94376-75-7
|
伊金霍洛旗|
澄城县|
株洲县|
内黄县|
南城县|
长武县|
鄂伦春自治旗|
静海县|
连山|
五原县|
通化县|
富源县|
固阳县|
美姑县|
晋江市|
赞皇县|
乐清市|
苏尼特右旗|
林口县|
东辽县|
盖州市|
基隆市|
临漳县|
鹿邑县|
会泽县|
漳浦县|
马龙县|
巴马|
金塔县|
自治县|
新闻|
中西区|
德格县|
孝昌县|
靖西县|
青田县|
徐汇区|
尼玛县|
资兴市|
鄂伦春自治旗|
蓬溪县|
|