ChemicalBook--->CAS DataBase List--->94376-75-7

94376-75-7

      • 94376-75-7 Structure

        94376-75-7 Structure
        IdentificationBack Directory
        [Name]

        alpha, oMega-Dipropionic acid hexaethylene glycol
        [CAS]

        94376-75-7
        [Synonyms]

        94376-75-7
        Bis-PEG7-COOH
        Bis-PEG7-acid
        Bis-PEG8-acid
        HOOC-PEG6-COOH
        COOH-PEG6-COOH
        COOH-PEG7-COOH
        Bis(3-PEG6)propionic acid
        HOOCCH2CH2O-PEG6-CH2CH2COOH
        α,ω-Dipropionic acid hexaethylene glycol
        4,7,10,13,16,19,22-Heptaoxapentacosanedioic acid
        alpha, oMega-Dipropionic acid hexaethylene glycol
        3-(2-{2-[2-(2-{2-[2-(2-Carboxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}-ethoxy)propionic acid
        [Molecular Formula]

        C18H34O11
        [MDL Number]

        MFCD11041125
        [MOL File]

        94376-75-7.mol
        [Molecular Weight]

        426.46
        Chemical PropertiesBack Directory
        [storage temp. ]

        Store at Room Tem.
        [form ]

        Viscous Liquid
        [color ]

        Colorless to light yellow
        Safety DataBack Directory
        [Symbol(GHS) ]

        Exclamation Mark (GHS07)
        GHS07
        [Signal word ]

        Warning
        [Hazard statements ]

        H302-H315-H319-H335
        [Precautionary statements ]

        P261-P305+P351+P338
        Hazard InformationBack Directory
        [Description]

        Bis-PEG7-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
        [Uses]

        Bis-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
        [Biological Activity]

        Bis-PEG7-acid is a PROTAC linker belonging to the PEG class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).
        [target]

        PEGs

        Cleavable

        [IC 50]

        PEGs; Cleavable Linker
        [References]

        [1] Marc Stefan ROBILLARD, et al. Tetrazines for high click conjugation yield in vivo and high click release yield. WO2019212356A1
        Spectrum DetailBack Directory
        [Spectrum Detail]

        alpha, oMega-Dipropionic acid hexaethylene glycol(94376-75-7)1HNMR
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