| Identification | Back Directory | [Name]
D-Cl-amidine | [CAS]
1404060-15-6 | [Synonyms]
D-Cl-amidine
D Cl amidine,DClamidine
Benzamide, N-[(1R)-1-(aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]- | [Molecular Formula]
C14H19ClN4O2 | [MDL Number]
MFCD32900724 | [MOL File]
1404060-15-6.mol | [Molecular Weight]
310.78 |
| Hazard Information | Back Directory | [Uses]
D-Cl-amidine is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity[1]. | [in vivo]
D-Cl-amidine, administered by iv at a dose of 2.5 mg/kg, is still detected after 2 h in serum at a concentration of ~21 nM and at 4 h at ~10 nM. D-Cl-amidine is still observed in the blood serum at a concentration of ～10 nM at 4 h when administered by ip at a dose of 10 mg/kg[1].
| [References]
[1] Bicker KL, et al. D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy. ACS Med Chem Lett. 2012 Oct 26;3(12):1081-1085. DOI:10.1021/ml300288d |
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