| Identification | Back Directory | [Name]
(R)-N-(1-amino-5-(2-chloroacetamidino)-1-oxopentan-2-yl)benzamide hydrochloride | [CAS]
2985338-61-0 | [Synonyms]
(R)-N-(1-amino-5-(2-chloroacetamidino)-1-oxopentan-2-yl)benzamide hydrochloride |
| Hazard Information | Back Directory | [Uses]
D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity[1]. | [in vivo]
D-Cl-amidine, administered by iv at a dose of 2.5 mg/kg, is still detected after 2 h in serum at a concentration of ~21 nM and at 4 h at ~10 nM. D-Cl-amidine is still observed in the blood serum at a concentration of ～10 nM at 4 h when administered by ip at a dose of 10 mg/kg[1].
| [References]
[1] Bicker KL, et al. D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy. ACS Med Chem Lett. 2012 Oct 26;3(12):1081-1085. DOI:10.1021/ml300288d |
|
|