| Identification | Back Directory | [Name]
C2 L-threo Ceramide (d18:1/2:0) | [CAS]
143615-69-4 | [Synonyms]
C2 L-threo Ceramide (d18:1/2:0) | [Molecular Formula]
C20H39NO3 | [MDL Number]
MFCD08703025 | [MOL File]
143615-69-4.mol | [Molecular Weight]
341.53 |
| Hazard Information | Back Directory | [Description]
C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.1 It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is 50% less than that stimulated by C2 ceramide . C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate (PMA; ) when used at a concentration of 10 μM.2 It also induces cell cycle arrest in the G0/G1 phase and a 7-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells.3,4
| [References]
1. Ghering, A.B., and Davidson, W.S. Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I J. Lipid Res. 47(12),2781-2788(2006).
2. Park, J., Li, Q., Chang, Y.T., et al. Inhibitory activity of a ceramide library in interleukin-4 production from activated T cells Bioorg. Med. Chem. 13(7),2589-2595(2005).
3. Baek, M.Y., Yoo, H.S., Nakaya, K., et al. Sphingolipid metabolic changes during chiral C2-ceramides induced apoptosis in human leukemia cells Arch. Pharm. Res. 24(2),144-149(2001).
4. Bielawska, A., Crane, H.M., Liotta, D., et al. Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide J. Biol. Chem. 268(35),26226-26232(1993). |
|
|