| Identification | Back Directory | [Name]
C6 L-threo Ceramide (d18:1/6:0) | [CAS]
189894-80-2 | [Synonyms]
C6 L-threo Ceramide (d18:1/6:0) | [Molecular Formula]
C24H47NO3 | [MDL Number]
MFCD08703024 | [MOL File]
189894-80-2.mol | [Molecular Weight]
397.63 |
| Chemical Properties | Back Directory | [Boiling point ]
574.7±50.0 °C(Predicted) | [density ]
0.946±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Chloroform: Soluble; DMF: 5 mg/ml; DMSO: Soluble; Ethanol: Soluble | [form ]
A solid | [pka]
13.53±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
C6 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.1,2 C6 L-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM).3 It is metabolically inactive and, unlike C6 L-erythro ceramide , C6 L-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase.2 C6 L-threo Ceramide enhances IL-4 production induced by phorbol 12-myristate 13-acetate (PMA; ) in EL4 T cells when used at a concentration of 10 μM.4 | [Uses]
C6 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides[1]. C6 L-threo Ceramide significantly inhibits IL-4 production in T cells. Anti-allergic agents[2]. | [storage]
Store at -20°C | [References]
1. Schwarz, A., and Futerman, A.H. Distinct roles for ceramide and glucosylceramide at different stages of neuronal growth J. Neurosci. 17(9),2929-2938(1997).
2. Paul, P., Kamisaka, Y., Marks, D.L., et al. Purification and characterization of UDP-glucose: Ceramide glucosyltransferase from rat liver Golgi membranes Curr. Opin. Struct. Biol. 271(4),2287-2293(1996).
3. Chang, Y.-T., Choi, J., Ding, S., et al. The synthesis and biological characterization of a ceramide library J. Am. Chem. Soc. 124(9),1856-1857(2002).
4. Park, J., Li, Q., Chang, Y.T., et al. Inhibitory activity of a ceramide library in interleukin-4 production from activated T cells Bioorg. Med. Chem. 13(7),2589-2595(2005). |
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