| Identification | Back Directory | [Name]
C6 D-threo Ceramide (d18:1/6:0) | [CAS]
189894-79-9 | [Synonyms]
C6 D-threo Ceramide (d18:1/6:0)
Hexanamide, N-[(1R,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]- | [Molecular Formula]
C24H47NO3 | [MDL Number]
MFCD08703022 | [MOL File]
189894-79-9.mol | [Molecular Weight]
397.63 |
| Chemical Properties | Back Directory | [Boiling point ]
574.7±50.0 °C(Predicted) | [density ]
0.946±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
A solid | [pka]
13.53±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlike C6 L-erythro ceramide , C6 D-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase. C6 D-threo Ceramide promotes survival of isolated rat spinal neurons when used at concentrations up to 2.5 μM but induces cell death at concentrations greater than 5 μM. It enhances IL-4 production induced by phorbol 12-myristate 13-acetate (PMA; ) in EL4 T cells when used at a concentration of 10 μM. [Matreya, LLC. Catalog No. 1809] | [Uses]
C6 D-Threo Ceramide (d18:1/6:0) is a bioactive sphingolipid and cell-permeable analog of ceramides. C6 D-Threo Ceramide (d18:1/6:0) enhances IL-4 production induced by Phorbol 12-myristate 13-acetate (HY-18739) in EL4 T cells[1][2]. | [IC 50]
IL-4 | [storage]
Store at -20°C | [References]
[1] Park J, et al. Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells. Bioorg Med Chem. 2005 Apr 1;13(7):2589-95. DOI:10.1016/j.bmc.2005.01.027
[2] Irie F, et al. Application of exogenous ceramide to cultured rat spinal motoneurons promotes survival or death by regulation of apoptosis depending on its concentrations. J Neurosci Res. 1998 Nov 15;54(4):475-85. DOI:10.1002/(SICI)1097-4547(19981115)54:4<475::AID-JNR5>3.0.CO;2-P |
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