| Identification | Back Directory | [Name]
TCO-PEG4-NHS ester | [CAS]
1613439-69-2 | [Synonyms]
TCO-PEG4-NHS ester (4E)-TCO-PEG4-NHS ester (Z)-2,5-dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate 5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(4-cycloocten-1-yl) 17-(2,5-dioxo-1-pyrrolidinyl) ester | [Molecular Formula]
C24H38N2O10 | [MDL Number]
MFCD28118912 | [MOL File]
1613439-69-2.mol | [Molecular Weight]
514.57 |
| Chemical Properties | Back Directory | [density ]
1.23±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Oil | [pka]
11.95±0.46(Predicted) | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h1-2,20H,3-19H2,(H,25,30)/b2-1- | [InChIKey]
ZKPMRASGLDBKPF-UPHRSURJSA-N | [SMILES]
C(OC1CCCC=CCC1)(=O)NCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O |c:6| |
| Hazard Information | Back Directory | [Description]
TCO-PEG4-NHS Ester is a click chemistry crosslinker. This reagent can be used to label antibodies, proteins and other primary amine containing molecule. The hydrophilic PEG spacer increases water-solubility and decreases steric hindrance during ligation. TCO enable fast click chemistry under mild condition | [Biological Activity]
TCO-PEG4-NHS ester is a PROTAC linker and belongs to the PEG class,it can be used to synthesize a series of PROTAC molecules.It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | [in vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
|
|
|
Tags:1613439-69-2
Related Product Information
|
|
1800507-93-0
1580501-97-8
1801863-88-6
1799962-26-7
1802913-21-8
2183473-16-5
1609659-01-9
2243569-24-4
2028288-77-7
1191901-33-3
1354323-64-0
|
鹿泉市|
涪陵区|
扎兰屯市|
子长县|
崇仁县|
大田县|
盱眙县|
阿鲁科尔沁旗|
阿瓦提县|
舞阳县|
兴安县|
营山县|
察隅县|
新巴尔虎左旗|
双峰县|
莫力|
黑水县|
玉龙|
汶川县|
郁南县|
溧水县|
澄城县|
浦北县|
平谷区|
南澳县|
郎溪县|
长泰县|
横峰县|
阳曲县|
贺兰县|
宁陕县|
景德镇市|
鄂伦春自治旗|
中阳县|
洞头县|
手游|
眉山市|
且末县|
重庆市|
金门县|
万载县|
|