1613439-69-2
中文名稱(chēng)
(4E)-TCO-PEG4-NHS ESTER
英文名稱(chēng)
TCO-PEG4-NHS ester
CAS
1613439-69-2
分子式
C24H38N2O10
分子量
514.57
MOL 文件
1613439-69-2.mol
更新日期
2026/07/14 17:33:04
1613439-69-2 結(jié)構(gòu)式
基本信息
中文別名
(4E)-反式環(huán)辛烯-四聚乙二醇-NHS 酯(4E)-反式環(huán)辛烯-四聚乙二醇-琥珀酰亞胺酯
英文別名
TCO-PEG4-NHS ester(4E)-TCO-PEG4-NHS ester
(Z)-2,5-dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate
5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(4-cycloocten-1-yl) 17-(2,5-dioxo-1-pyrrolidinyl) ester
所屬類(lèi)別
催化劑及助劑：聚合物物理化學(xué)性質(zhì)
密度1.23±0.1 g/cm3(Predicted)
溶解度Soluble in DMSO, DCM, DMF
酸度系數(shù)(pKa)11.95±0.46(Predicted)
形態(tài)Oil
顏色Colorless to light yellow
InChIInChI=1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h1-2,20H,3-19H2,(H,25,30)/b2-1-
InChIKeyZKPMRASGLDBKPF-UPHRSURJSA-N
SMILESC(OC1CCCC=CCC1)(=O)NCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O |c:6|
(4E)-TCO-PEG4-NHS ESTER價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | XW02161343969203 | 試劑TCO-PEG4-NHS ester TCO-PEG4-NHS ester | 1613439-69-2 | 250mg | 2211元 |
| 2026/06/05 | XW02161343969202 | 試劑TCO-PEG4-NHS ester TCO-PEG4-NHS ester | 1613439-69-2 | 100mg | 934元 |
| 2026/06/05 | XW02161343969201 | 試劑TCO-PEG4-NHS ester TCO-PEG4-NHS ester | 1613439-69-2 | 50mg | 685元 |
常見(jiàn)問(wèn)題列表
生物活性
TCO-PEG4-NHS ester 是一種 PROTAC 連接橋，屬于 PEG 類(lèi)。TCO-PEG4-NHS ester 可用于合成一系列 PROTAC 分子。TCO-PEG4-NHS ester 是一種可降解 (cleavable) 的 ADC 連接橋，用于抗體藥物結(jié)合物 (ADCs) 的合成。靶點(diǎn)
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Cleavable
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PEGs
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體外研究
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.