| Identification | Back Directory | [Name]
DMU2105 | [CAS]
1821143-79-6 | [Synonyms]
2-Propen-1-one, 3-(2-naphthalenyl)-1-(3-pyridinyl)-, (2E)- | [Molecular Formula]
C18H13NO | [MDL Number]
MFCD10617787 | [MOL File]
1821143-79-6.mol | [Molecular Weight]
259.3 |
| Chemical Properties | Back Directory | [Boiling point ]
463.7±37.0 °C(Predicted) | [density ]
1.194±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
2.89±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
DMU2105 is a potent and specific CYP1B1 inhibitor, with IC50s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively. | [IC 50]
CYP1B1: 10 nM (IC50); CYP1A1: 742 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Horley NJ, et al. Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines. Eur J Med Chem. 2017 Mar 31;129:159-174. DOI:10.1016/j.ejmech.2017.02.016 |
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| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
|