1821143-79-6
1821143-79-6 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)463.7±37.0 °C(Predicted)
密度1.194±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)2.89±0.10(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
1821143-79-6價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2026/06/05 | HY-101284 | 1821143-79-6 DMU2105 | 1821143-79-6 | 5 mg | 880元 |
| 2026/06/05 | HY-101284 | 1821143-79-6 DMU2105 | 1821143-79-6 | 10 mM * 1 mL in DMSO | 968元 |
| 2026/06/05 | HY-101284 | 1821143-79-6 DMU2105 | 1821143-79-6 | 10 mg | 1400元 |
常見問題列表
生物活性
DMU2105 是有效的特異性細(xì)胞色素 P4501B1 (CYP1B1) 的抑制劑，其對(duì) CYP1B1 和 CYP1A1 的 IC50 值分別為 10 nM 和 742 nM。靶點(diǎn)
|
CYP1B1 10 nM (IC 50 ) |
CYP1A1 742 nM (IC 50 ) |
體外研究
DMU2105 (Compound 7k) shows 74 and 120-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2105 however, the EC 50 goes down to 1 μM indicating that the cells have suffered from toxicity which may have been mediated by CYP1B1 inhibition. Un-transfected cells (HEK293: pcDNA3.1), when treated with cisplatin and DMU2105 (10×IC 50 ) do not show any perceptible decrease of cisplatin EC 50 (8.5 μM ± 0.9).