| Identification | Back Directory | [Name]
2-Pyrrolidinecarboxamide, 1-[[1-[4-(difluoromethoxy)phenyl]-4,4-difluorocyclohexyl]carbonyl]-4-fluoro-N-1H-pyrazolo[4,3-b]pyridin-5-yl-, (2R,4R)- | [CAS]
2259641-71-7 | [Synonyms]
CBP/p300-IN-10
2-Pyrrolidinecarboxamide, 1-[[1-[4-(difluoromethoxy)phenyl]-4,4-difluorocyclohexyl]carbonyl]-4-fluoro-N-1H-pyrazolo[4,3-b]pyridin-5-yl-, (2R,4R)- | [Molecular Formula]
C25H24F5N5O3 | [MOL File]
2259641-71-7.mol | [Molecular Weight]
537.48 |
| Chemical Properties | Back Directory | [Boiling point ]
754.2±60.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
10.48±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CBP/p300-IN-10 is a highly potent histone acetyltransferase EP300 and CREBBP with IC50 values of 26 nM and 39 nM, respectively. CBP/p300-IN-10 can be used to research anticancer[1]. | [IC 50]
EP300: 26 nM (IC50); CREBBP: 39 nM (IC50) | [References]
[1] Naito, Hiroyuki, et al. Preparation of amino acid amide derivatives such as L- and D-prolinamide derivatives as Ep300/CREBBP inhibitors. WO2018235966A1 |
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